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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 577 African American or Afro-Caribbean cases, 120,082 African American or Afro-Caribbean controls, 3,004 European ancestry cases, 442,498 European ancestry controls, 395 Hispanic or Latin American cases, 58,716 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 1.95 lower (95% confidence interval 1.88-2.01); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 16, band 16q22.2 — in an intron of PKD1L3.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Other disorders of gallbladder (PheCode 575.7) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Other disorders of gallbladder (PheCode 575.7).
T/TPublished research associates this genotype with typical/baseline likelihood of Other disorders of gallbladder (PheCode 575.7) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs139021969
What is rs139021969?
rs139021969 is a single position in the genome, in or near the PKD1L3 gene. Published research associates it with other disorders of gallbladder (phecode 575.7). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs139021969 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs139021969 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Other disorders of gallbladder (PheCode 575.7) (rs139021969). MyGeneLog™. https://www.mygenelog.com/variants/rs139021969