Standard

FTLD-TDP subtype A

near RPL18AP17 · rs138959102

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 193 European ancestry cases, 3,153 European ancestry controls.

The effect Each copy of the T allele carried 8.41 times the odds of FTLD-TDP subtype A (95% confidence interval 3.95-17.88); p = 3 × 10⁻⁸.

Where it sits Chromosome 13, band 13q21.33 — between genes, 39.2 kb from RPL18AP17.

What each result means

C/C No copy of the version the research linked to FTLD-TDP subtype A. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to FTLD-TDP subtype A. That is a smaller link than two copies.

T/T Two copies of the version the research linked to FTLD-TDP subtype A. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME

and 107 more — show all

Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Tempini MLG, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene CD, Jin LW, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL 3rd, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Dalgard CL, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R

Nature communications · 2025 · PMID 40280976 · open access

Questions about rs138959102

What is rs138959102?

rs138959102 is a single position in the genome, in or near the near RPL18AP17 gene. Published research associates it with ftld-tdp subtype a. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs138959102 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138959102 come from?

GWAS Catalog, Nature communications 2025, PMID:40280976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

FTLD-TDP subtype A (rs138959102). MyGeneLog™. https://www.mygenelog.com/variants/rs138959102

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