Sensitive

Venous thromboembolism adjusted for sickle cell variant rs77121243-T

LEMD3 · rs138916004

Where this position leads

Condition: Venous Thromboembolism

rs138916004 Condition: Venous Thromboembolism Venous Thromboembolism Condition rs138916004 rs138916004 LEMD3

What the study found

Who was studied 393 African American cases, 4,941 African American controls..

The effect Each copy of the G allele carried 3.17 times the odds of Venous thromboembolism adjusted for sickle cell variant rs77121243-T (95% confidence interval 2.131-4.719); p = 1 × 10−8.

How common The G allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 12, band 12q14.3 — in an intron of LEMD3.

What each result means

A/A No copy of the version the research linked to Venous thromboembolism adjusted for sickle cell variant rs77121243-T. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Venous thromboembolism adjusted for sickle cell variant rs77121243-T. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Venous thromboembolism adjusted for sickle cell variant rs77121243-T. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs138916004

What is rs138916004?

rs138916004 is a single position in the genome, in or near the LEMD3 gene. Published research associates it with venous thromboembolism adjusted for sickle cell variant rs77121243-t. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs138916004 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs138916004 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138916004 come from?

GWAS Catalog, Thromb Haemost 2017, PMID:28203683. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Venous thromboembolism adjusted for sickle cell variant rs77121243-T (rs138916004). MyGeneLog™. https://www.mygenelog.com/variants/rs138916004

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