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Total cholesterol levels (MTAG)

DNMT1 · rs138847616

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 125,000 African ancestry individuals (MTAG boosted by high-density lipoprotein and triglyceride samples).

The effect Each copy of the C allele shifted the measure 0.187 lower (95% confidence interval 0.14-0.23); p = 4 × 10⁻¹⁵.

Where it sits Chromosome 19, band 19p13.2 — in an intron of DNMT1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total cholesterol levels (MTAG) compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total cholesterol levels (MTAG).

T/T Published research associates this genotype with typical/baseline likelihood of Total cholesterol levels (MTAG) — no copies of the reported risk allele.

Source

Multi-trait discovery and fine-mapping of lipid loci in 125,000 individuals of African ancestry

Kamiza AB, Touré SM, Zhou F, Soremekun O, Cissé C, Wélé M, Touré AM, Nashiru O, Corpas M, Nyirenda M, Crampin A, Shaffer J

and 6 more — show all

Doumbia S, Zeggini E, Morris AP, Asimit JL, Chikowore T, Fatumo S

Nature communications · 2023 · PMID 37669986 · open access

Questions about rs138847616

What is rs138847616?

rs138847616 is a single position in the genome, in or near the DNMT1 gene. Published research associates it with total cholesterol levels (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs138847616 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138847616 come from?

GWAS Catalog, Nature communications 2023, PMID:37669986. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Total cholesterol levels (MTAG) (rs138847616). MyGeneLog™. https://www.mygenelog.com/variants/rs138847616

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