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Who was studied 17,101 European ancestry cases, 721,947 European ancestry controls.
The effect
Each copy of the C allele carried 1.19 times the odds of Kidney stone disease (95% confidence interval 1.13-1.25); p = 5 × 10−10.
How common The C allele had a frequency of about 93% in the people studied.
Where it sits Chromosome 3, band 3p21.2 — in an intron of POC1A.
What each result means
C/CTwo copies of the version the research linked to Kidney stone disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Kidney stone disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Kidney stone disease. This is the starting point the study compared everyone against.
Journal of the American Society of Nephrology : JASN · 2023 · PMID 37787550 · open access
Questions about rs138789058
What is rs138789058?
rs138789058 is a single position in the genome, in or near the POC1A gene. Published research associates it with kidney stone disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs138789058 linked to?
On MyGeneLog this position is linked to Urolithiasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs138789058 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs138789058 come from?
GWAS Catalog, Journal of the American Society of Nephrology : JASN 2023, PMID:37787550. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 102215Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others5Total10Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Kidney stone disease (rs138789058). MyGeneLog™. https://www.mygenelog.com/variants/rs138789058