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Ulcerative colitis

TOM1 · rs138788

Where this position leads

Condition: Ulcerative Colitis

rs138788 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs138788 rs138788 TOM1

What the study found

Who was studied 12,366 European and unknown ancestry cases, 33,609 European and unknown ancestry controls.

The effect Each copy of the A allele carried 1.09 times the odds of Ulcerative colitis (95% confidence interval 1.06–1.13); p = 3 × 10−8.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 22, band 22q12.3 — in an intron of TOM1.

What each result means

A/A Two copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
Source

Questions about rs138788

What is rs138788?

rs138788 is a single position in the genome, in or near the TOM1 gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs138788 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs138788 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138788 come from?

GWAS Catalog, Nat Genet 2017, PMID:28067908. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ulcerative colitis (rs138788). MyGeneLog™. https://www.mygenelog.com/variants/rs138788

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