TRPS1 · rs1384810
Where this position leads
Condition: Blood Cell Counts
Strength of the evidence
Its strongest genetic-study result is p = 10−10, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 46,904 European ancestry males; replicated in 80,822 European ancestry males.
The effect Each copy of the C allele shifted the measure 0.0237 lower; p = 2 × 10−10.
How common The C allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 8, band 8q23.3 — in an intron of TRPS1.
rs1384810 is a single position in the genome, in or near the TRPS1 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Hemoglobin concentration (rs1384810). MyGeneLog™. https://www.mygenelog.com/variants/rs1384810