Sensitive

Major depressive disorder in trauma-unexposed individuals

THRB · rs138272922

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Major depressive disorder in trauma-unexposed individuals compared to the general population. (GWAS Catalog, Mol Psychiatry 2020, PMID:31969693)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Major depressive disorder in trauma-unexposed individuals. (GWAS Catalog, Mol Psychiatry 2020, PMID:31969693)
T/T Published research associates this genotype with typical/baseline likelihood of Major depressive disorder in trauma-unexposed individuals — no copies of the reported risk allele. (GWAS Catalog, Mol Psychiatry 2020, PMID:31969693)

Source: GWAS Catalog, Mol Psychiatry 2020, PMID:31969693

Questions about rs138272922

What is rs138272922?

rs138272922 is a single position in the genome, in or near the THRB gene. Published research associates it with major depressive disorder in trauma-unexposed individuals. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs138272922 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138272922 come from?

GWAS Catalog, Mol Psychiatry 2020, PMID:31969693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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