Major depressive disorder in trauma-unexposed individuals
THRB · rs138272922
2 3942117213117Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot2Amazon1Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 9,487 European ancestry cases, 39,677 European ancestry controls.
The effect
Each copy of the C allele carried 1.16 times the odds of Major depressive disorder in trauma-unexposed individuals (95% confidence interval 1.11-1.21); p = 5 × 10−8.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 3, band 3p24.2 — in an intron of THRB.
What each result means
C/CTwo copies of the version the research linked to Major depressive disorder in trauma-unexposed individuals. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Major depressive disorder in trauma-unexposed individuals. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Major depressive disorder in trauma-unexposed individuals. This is the starting point the study compared everyone against.
Molecular psychiatry · 2020 · PMID 31969693 · open access
Questions about rs138272922
What is rs138272922?
rs138272922 is a single position in the genome, in or near the THRB gene. Published research associates it with major depressive disorder in trauma-unexposed individuals. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs138272922 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs138272922 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs138272922 come from?
GWAS Catalog, Mol Psychiatry 2020, PMID:31969693. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 3942117213117Reads by AI crawlersClaude4ChatGPT2Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot2Amazon1Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total39Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Major depressive disorder in trauma-unexposed individuals (rs138272922). MyGeneLog™. https://www.mygenelog.com/variants/rs138272922