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Bioavailable testosterone levels

ARHGAP6 · rs138271349

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 382,988 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0228 higher (95% confidence interval 0.015-0.03); p = 4 × 10⁻¹⁰.

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome X, band Xp22.2 — in an intron of ARHGAP6.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Bioavailable testosterone levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Bioavailable testosterone levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Bioavailable testosterone levels compared to the general population.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs138271349

What is rs138271349?

rs138271349 is a single position in the genome, in or near the ARHGAP6 gene. Published research associates it with bioavailable testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs138271349 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138271349 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bioavailable testosterone levels (rs138271349). MyGeneLog™. https://www.mygenelog.com/variants/rs138271349

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