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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 4,642 European ancestry women.
The effect
Each copy of the C allele shifted the measure 0.416 higher (95% confidence interval 0.29-0.55); p = 3 × 10−10.
Where it sits Chromosome 4, band 4q13.3 — between genes, 32.7 kb from AREG.
What each result means
A/ANo copy of the version the research linked to Sphingomyelin (d34:1) levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Sphingomyelin (d34:1) levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Sphingomyelin (d34:1) levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the American Heart Association · 2022 · PMID 36193934 · open access
Questions about rs138270540
What is rs138270540?
rs138270540 is a single position in the genome, in or near the near AREG gene. Published research associates it with sphingomyelin (d34:1) levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs138270540 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs138270540 come from?
GWAS Catalog, Journal of the American Heart Association 2022, PMID:36193934. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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