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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 437,267 European ancestry individuals; replicated in 315,572 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00407 lower (95% confidence interval 0.0028-0.0053); p = 2 × 10−10.
How common The G allele had a frequency of about 89% in the people studied.
Where it sits Chromosome 15, band 15q14 — between genes, 51.7 kb from THBS1.
What each result means
C/CNo copy of the version the research linked to Liver enzyme levels (alanine transaminase). This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Liver enzyme levels (alanine transaminase). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Liver enzyme levels (alanine transaminase). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33972514 · open access
Questions about rs1382445
What is rs1382445?
rs1382445 is a single position in the genome, in or near the THBS1 gene. Published research associates it with liver enzyme levels (alanine transaminase). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs1382445 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1382445 come from?
GWAS Catalog, Nature communications 2021, PMID:33972514. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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