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Diffuse large B-cell non-Hodgkin lymphoma

near HLA-DRA · rs138094736

Where this position leads

Condition: Hodgkin Lymphoma

rs138094736 Condition: Hodgkin Lymphoma Hodgkin Lymphoma Condition rs138094736 rs138094736 near HLA-DRA

What the study found

Who was studied 175 Israeli Jewish cases, 324 Israeli Jewish controls, 229 Palestinian Arab or North African Israeli Jewish cases, 392 Palestinian Arab or North African Israeli Jewish controls.

The effect Each copy of the G allele carried 3.09 times the odds of Diffuse large B-cell non-Hodgkin lymphoma (95% confidence interval 2.14-4.47); p = 2 × 10−9.

How common The G allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of HLA-DRB9.

What each result means

A/A No copy of the version the research linked to Diffuse large B-cell non-Hodgkin lymphoma. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Diffuse large B-cell non-Hodgkin lymphoma. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Diffuse large B-cell non-Hodgkin lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs138094736

What is rs138094736?

rs138094736 is a single position in the genome, in or near the near HLA-DRA gene. Published research associates it with diffuse large b-cell non-hodgkin lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs138094736 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs138094736 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs138094736 come from?

GWAS Catalog, British journal of haematology 2025, PMID:40887045. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Diffuse large B-cell non-Hodgkin lymphoma (rs138094736). MyGeneLog™. https://www.mygenelog.com/variants/rs138094736

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