Standard
Serum urate levels
near NPM1P22 · rs138014033
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 630,117 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.4 higher (95% confidence interval 1.19-1.61); p = 1 × 10−38.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 13, band 13q21.32 — between genes, 30.3 kb from NPM1P22.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum urate levels compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum urate levels.
G/G
Published research associates this genotype with typical/baseline likelihood of Serum urate levels — no copies of the reported risk allele.
Source
A genome-wide association analysis reveals new pathogenic pathways in gout
Major TJ,
Takei R,
Matsuo H,
Leask MP,
Sumpter NA,
Topless RK,
Shirai Y,
Wang W,
Cadzow MJ,
Phipps-Green AJ,
Li Z,
Ji A
and 86 more — show all
Merriman ME,
Morice E,
Kelley EE,
Wei WH,
McCormick SPA,
Bixley MJ,
Reynolds RJ,
Saag KG,
Fadason T,
Golovina E,
O'Sullivan JM,
Stamp LK,
Dalbeth N,
Abhishek A,
Doherty M,
Roddy E,
Jacobsson LTH,
Kapetanovic MC,
Melander O,
Andrés M,
Pérez-Ruiz F,
Torres RJ,
Radstake T,
Jansen TL,
Janssen M,
Joosten LAB,
Liu R,
Gaal OI,
Crişan TO,
Rednic S,
Kurreeman F,
Huizinga TWJ,
Toes R,
Lioté F,
Richette P,
Bardin T,
Ea HK,
Pascart T,
McCarthy GM,
Helbert L,
Stibůrková B,
Tausche AK,
Uhlig T,
Vitart V,
Boutin TS,
Hayward C,
Riches PL,
Ralston SH,
Campbell A,
MacDonald TM,
Nakayama A,
Takada T,
Nakatochi M,
Shimizu S,
Kawamura Y,
Toyoda Y,
Nakaoka H,
Yamamoto K,
Matsuo K,
Shinomiya N,
Ichida K,
Lee C,
Bradbury LA,
Brown MA,
Robinson PC,
Buchanan RRC,
Hill CL,
Lester S,
Smith MD,
Rischmueller M,
Choi HK,
Stahl EA,
Miner JN,
Solomon DH,
Cui J,
Giacomini KM,
Brackman DJ,
Jorgenson EM,
Liu H,
Susztak K,
Shringarpure S,
So A,
Okada Y,
Li C,
Shi Y,
Merriman TR
Nature genetics · 2024 · PMID 39406924
Questions about rs138014033
What is rs138014033?
rs138014033 is a single position in the genome, in or near the near NPM1P22 gene. Published research associates it with serum urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs138014033 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs138014033 come from?
GWAS Catalog, Nature genetics 2024, PMID:39406924. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Serum urate levels (rs138014033). MyGeneLog™. https://www.mygenelog.com/variants/rs138014033
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