Allergy/adverse effect of penicillin (PheCode 960.2)
STUM · rs137927126
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What the study found
Who was studied 555 African American or Afro-Caribbean cases, 120,321 African American or Afro-Caribbean controls, 1,733 European ancestry cases, 445,584 European ancestry controls, 234 Hispanic or Latin American cases, 59,258 Hispanic or Latin American controls.
The effect
Each copy of the C allele shifted the measure 2.42 lower (95% confidence interval 2.38-2.47); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 1, band 1q42.12 — in an intron of STUM.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Allergy/adverse effect of penicillin (PheCode 960.2) compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Allergy/adverse effect of penicillin (PheCode 960.2).
T/TPublished research associates this genotype with typical/baseline likelihood of Allergy/adverse effect of penicillin (PheCode 960.2) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs137927126
What is rs137927126?
rs137927126 is a single position in the genome, in or near the STUM gene. Published research associates it with allergy/adverse effect of penicillin (phecode 960.2). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs137927126 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs137927126 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Allergy/adverse effect of penicillin (PheCode 960.2) (rs137927126). MyGeneLog™. https://www.mygenelog.com/variants/rs137927126