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Feeling worry

GOSR2 · rs1378358

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Feeling worry — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling worry.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling worry compared to the general population.

Source

Item-level analyses reveal genetic heterogeneity in neuroticism

Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S

Nature communications · 2018 · PMID 29500382 · open access

Questions about rs1378358

What is rs1378358?

rs1378358 is a single position in the genome, in or near the GOSR2 gene. Published research associates it with feeling worry. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1378358 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1378358 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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