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Essential hypertension (PheCode 401.1)

SLC27A6 · rs1363470

Where this position leads

Condition: Blood Pressure

rs1363470 Condition: Blood Pressure Blood Pressure Condition rs1363470 rs1363470 SLC27A6

What the study found

Who was studied 93,857 African American or Afro-Caribbean cases, 22,988 African American or Afro-Caribbean controls, 35,551 Hispanic or Latin American cases, 21,134 Hispanic or Latin American controls, 3,880 East Asian ancestry cases, 2,626 East Asian ancestry controls, 320,429 European ancestry cases, 107,275 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0463 lower (95% confidence interval 0.034-0.058); p = 6 × 10−13.

How common The T allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 5, band 5q23.3 — in an intron of SLC27A6.

What each result means

C/C No copy of the version the research linked to Essential hypertension (PheCode 401.1). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Essential hypertension (PheCode 401.1). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Essential hypertension (PheCode 401.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs1363470

What is rs1363470?

rs1363470 is a single position in the genome, in or near the SLC27A6 gene. Published research associates it with essential hypertension (phecode 401.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1363470 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs1363470 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1363470 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Essential hypertension (PheCode 401.1) (rs1363470). MyGeneLog™. https://www.mygenelog.com/variants/rs1363470

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