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Its strongest genetic-study result is p = 10−14, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 519,288 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0183 SD unit higher (95% confidence interval 0.014-0.023); p = 1 × 10−14.
How common The T allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 16, band 16q12.1 — in an intron of ZNF423.
What each result means
C/CNo copy of the version the research linked to Neutrophil count. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Neutrophil count. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Neutrophil count. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs1362623 is a single position in the genome, in or near the ZNF423 gene. Published research associates it with neutrophil count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1362623 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs1362623 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1362623 come from?
GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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