Standard

Insomnia

near POLR2DP2 · rs1358393

Where this position leads

Condition: Insomnia

rs1358393 Condition: Insomnia Insomnia Condition rs1358393 rs1358393 near POLR2DP2

What the study found

Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.01 lower (95% confidence interval 0.008-0.012); p = 1 × 10−28.

Where it sits Chromosome 7, band 7q31.2 — between genes, 57 kb from POLR2DP2.

What each result means

G/G No copy of the version the research linked to Insomnia. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Insomnia. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Insomnia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1358393

What is rs1358393?

rs1358393 is a single position in the genome, in or near the near POLR2DP2 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1358393 linked to?

On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.

Does having rs1358393 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1358393 come from?

GWAS Catalog, Nature genetics 2022, PMID:35835914. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insomnia (rs1358393). MyGeneLog™. https://www.mygenelog.com/variants/rs1358393

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