A/APublished research associates this genotype with typical/baseline likelihood of Worry/vulnerability (special factor of neuroticism) — no copies of the reported risk allele. (GWAS Catalog, Mol Psychiatry 2019, PMID:30867560)
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Worry/vulnerability (special factor of neuroticism). (GWAS Catalog, Mol Psychiatry 2019, PMID:30867560)
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Worry/vulnerability (special factor of neuroticism) compared to the general population. (GWAS Catalog, Mol Psychiatry 2019, PMID:30867560)
Molecular psychiatry · 2020 · PMID 30867560 · open access
Questions about rs1356493
What is rs1356493?
rs1356493 is a single position in the genome, in or near the ENSG00000225421 gene. Published research associates it with worry/vulnerability (special factor of neuroticism). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1356493 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs1356493 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1356493 come from?
GWAS Catalog, Mol Psychiatry 2019, PMID:30867560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.