Worry/vulnerability (special factor of neuroticism)
ENSG00000225421 · rs1356493
0 432235222124Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity3Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others24Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 270,059 British ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00752 lower (95% confidence interval 0.0049-0.0102); p = 3 × 10−8.
Where it sits Chromosome 2, band 2q33.1 — in an intron of LOC105373831.
What each result means
A/ANo copy of the version the research linked to Worry/vulnerability (special factor of neuroticism). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Worry/vulnerability (special factor of neuroticism). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Worry/vulnerability (special factor of neuroticism). That is the strongest link of the three results. A link in a study is not a diagnosis.
Molecular psychiatry · 2020 · PMID 30867560 · open access
Questions about rs1356493
What is rs1356493?
rs1356493 is a single position in the genome, in or near the ENSG00000225421 gene. Published research associates it with worry/vulnerability (special factor of neuroticism). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1356493 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs1356493 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1356493 come from?
GWAS Catalog, Mol Psychiatry 2019, PMID:30867560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 432235222124Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity3Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others24Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Worry/vulnerability (special factor of neuroticism) (rs1356493). MyGeneLog™. https://www.mygenelog.com/variants/rs1356493