Sensitive

Polycystic ovary syndrome

ERBB4 · rs1351592

Where this position leads

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Polycystic ovary syndrome — no copies of the reported risk allele.

C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Polycystic ovary syndrome.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Polycystic ovary syndrome compared to the general population.

Source

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome

Day FR, Hinds DA, Tung JY, Stolk L, Styrkarsdottir U, Saxena R, Bjonnes A, Broer L, Dunger DB, Halldorsson BV, Lawlor DA, Laval G

and 15 more — show all

Mathieson I, McCardle WL, Louwers Y, Meun C, Ring S, Scott RA, Sulem P, Uitterlinden AG, Wareham NJ, Thorsteinsdottir U, Welt C, Stefansson K, Laven JSE, Ong KK, Perry JRB

Nature communications · 2015 · PMID 26416764 · open access

Questions about rs1351592

What is rs1351592?

rs1351592 is a single position in the genome, in or near the ERBB4 gene. Published research associates it with polycystic ovary syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1351592 linked to?

On MyGeneLog this position is linked to Polycystic Ovary Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs1351592 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1351592 come from?

GWAS Catalog, Nat Commun 2015, PMID:26416764. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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