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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 997 European ancestry individuals; replicated in 338 Greater Middle Eastern (Middle Eastern, North African or Persian), South Asian ancestry, Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.533 higher (95% confidence interval 0.41-0.65); p = 4 × 10−18.
Where it sits Chromosome 22, band 22q12.3 — in an intron of SYN3.
What each result means
C/CTwo copies of the version the research linked to Metalloproteinase inhibitor 3 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Metalloproteinase inhibitor 3 levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Metalloproteinase inhibitor 3 levels. This is the starting point the study compared everyone against.
Nature communications · 2017 · PMID 28240269 · open access
Questions about rs135150
What is rs135150?
rs135150 is a single position in the genome, in or near the SYN3 gene. Published research associates it with metalloproteinase inhibitor 3 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs135150 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs135150 come from?
GWAS Catalog, Nature communications 2017, PMID:28240269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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