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Height

EFEMP1 · rs1346786

Where this position leads

Conditions: Height, Inguinal Hernia

rs1346786 Condition: Height Height Condition Condition: Inguinal Hernia Inguinal Hernia Condition rs1346786 rs1346786 EFEMP1

What the study found

Who was studied 5,314,291 European ancestry, Hispanic or Latin American, East Asian ancestry, African ancestry, South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0502 higher (95% confidence interval 0.049-0.052); p = 1 × 10−300.

How common The C allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — in an intron of EFEMP1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Height compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Height.
T/T Published research associates this genotype with typical/baseline likelihood of Height — no copies of the reported risk allele.
Source

From our blog

A height chart on a wall, with two of its marks leading off to a knee and to the abdominal wall

Your Height Genes Have Second Jobs: Meet GDF5 and EFEMP1

The stretches of DNA that set your height do other work too. In the records of three large studies, the taller…

Questions about rs1346786

What is rs1346786?

rs1346786 is a single position in the genome, in or near the EFEMP1 gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1346786 linked to?

On MyGeneLog this position is linked to Height, Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs1346786 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1346786 come from?

GWAS Catalog, Nature 2022, PMID:36224396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Height (rs1346786). MyGeneLog™. https://www.mygenelog.com/variants/rs1346786

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