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Who was studied 3,183 European ancestry cases, 773,214 European ancestry controls, 6,034 Asian ancestry cases, 15,071 Asian ancestry controls.
The effect
The reported allele is C; the catalogue records no effect size
; p = 3 × 10−8.
How common The C allele had a frequency of about 25% in the people studied.
Where it sits Chromosome 22, band 22q12.1 — in an intron of TTC28.
What each result means
C/CTwo copies of the version the research linked to Glaucoma (primary angle closure). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Glaucoma (primary angle closure). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Glaucoma (primary angle closure). This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 41238566 · open access
Questions about rs134545
What is rs134545?
rs134545 is a single position in the genome, in or near the TTC28 gene. Published research associates it with glaucoma (primary angle closure). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs134545 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs134545 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs134545 come from?
GWAS Catalog, Nature communications 2025, PMID:41238566. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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