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Psoriasis

HLA-B · rs13437088

Where this position leads

Condition: Psoriasis

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs13437088 Condition: Psoriasis Psoriasis Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs13437088 rs13437088 HLA-B

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2012, PMID:23143594)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis. (GWAS Catalog, Nat Genet 2012, PMID:23143594)
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population. (GWAS Catalog, Nat Genet 2012, PMID:23143594)
Source
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH
and 53 more — show all
McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CC, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CE, Reis A, Kere J, Nair RP, Franke A, Barker JN, Abecasis GR, Elder JT, Trembath RC
Collaborative Association Study of Psoriasis (CASP) · Genetic Analysis of Psoriasis Consortium · Psoriasis Association Genetics Extension · Wellcome Trust Case Control Consortium 2
Nature genetics · 2012 · PMID 23143594 · open access

Questions about rs13437088

What is rs13437088?

rs13437088 is a single position in the genome, in or near the HLA-B gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13437088 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does rs13437088 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs13437088 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13437088 come from?

GWAS Catalog, Nat Genet 2012, PMID:23143594. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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