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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 47,740 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0382 lower (95% confidence interval 0.026-0.05); p = 3 × 10−10.
Where it sits Chromosome 2, band 2q35 — between genes, 0.5 kb from SPEG.
What each result means
C/CTwo copies of the version the research linked to Cardiac MRI latent phenotype (Z29_S1). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Cardiac MRI latent phenotype (Z29_S1). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cardiac MRI latent phenotype (Z29_S1). This is the starting point the study compared everyone against.
Nature communications · 2026 · PMID 42373625 · open access
Questions about rs13386459
What is rs13386459?
rs13386459 is a single position in the genome, in or near the near SPEG gene. Published research associates it with cardiac mri latent phenotype (z29_s1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs13386459 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13386459 come from?
GWAS Catalog, Nature communications 2026, PMID:42373625. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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