Sensitive

Systemic lupus erythematosus

IRF8 · rs13332649

Where this position leads

Condition: Systemic Lupus Erythematosus

rs13332649 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs13332649 rs13332649 IRF8

What the study found

Who was studied 5,201 European ancestry cases, 9,066 European ancestry controls.

The effect Each copy of the A allele carried 1.34 times the odds of Systemic lupus erythematosus; p = 2 × 10−18.

Where it sits Chromosome 16, band 16q24.1 — between genes, 2.2 kb from LINC02132.

What each result means

A/A Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
G/G No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
Source

Questions about rs13332649

What is rs13332649?

rs13332649 is a single position in the genome, in or near the IRF8 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13332649 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs13332649 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13332649 come from?

GWAS Catalog, Nat Genet 2015, PMID:26502338. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs13332649). MyGeneLog™. https://www.mygenelog.com/variants/rs13332649

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