TNC · rs13321
Where this position leads
Condition: Celiac Disease
What the study found
Who was studied 47,745 European ancestry individuals.
The effect Each copy of the G allele shifted the measure 0.0891 lower (95% confidence interval 0.077-0.101); p = 1 × 10−56.
How common The G allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 9, band 9q33.1 — a missense change in TNC.
What ClinVar records
Classification
Benign for Autosomal dominant nonsyndromic hearing loss 56; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2021-09-10.
ClinVar record 1259794 NM_002160.4(TNC):c.6022G>C (p.Glu2008Gln)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs13321 is a single position in the genome, in or near the TNC gene. Published research associates it with tnc protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TNC protein levels (rs13321). MyGeneLog™. https://www.mygenelog.com/variants/rs13321