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White blood cell count (monocyte)

CCDC28 · rs13277237

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 11,809 Hispanic/Latino American individuals; replicated in up to 7,200 Hispanic/Latino American individuals.

The effect Each copy of the G allele shifted the measure 0.0099 higher (95% confidence interval 0.0072-0.0126); p = 6 × 10⁻¹².

How common The G allele had a frequency of about 46% in the people studied.

Where it sits Chromosome 8, band 8q24.21 — in a regulatory region of CCDC26.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of White blood cell count (monocyte) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with White blood cell count (monocyte).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of White blood cell count (monocyte) compared to the general population.

Source

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos

Jain D, Hodonsky CJ, Schick UM, Morrison JV, Minnerath S, Brown L, Schurmann C, Liu Y, Auer PL, Laurie CA, Taylor KD, Browning BL

and 9 more — show all

Papanicolaou G, Browning SR, Loos RJF, North KE, Thyagarajan B, Laurie CC, Thornton TA, Sofer T, Reiner AP

Human molecular genetics · 2017 · PMID 28158719

Questions about rs13277237

What is rs13277237?

rs13277237 is a single position in the genome, in or near the CCDC28 gene. Published research associates it with white blood cell count (monocyte). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13277237 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13277237 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28158719. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White blood cell count (monocyte) (rs13277237). MyGeneLog™. https://www.mygenelog.com/variants/rs13277237

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