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Myeloproliferative neoplasms

JAK2 · rs1327494

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Myeloproliferative neoplasms — no copies of the reported risk allele. (GWAS Catalog, Nature 2020, PMID:33057200)

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myeloproliferative neoplasms. (GWAS Catalog, Nature 2020, PMID:33057200)

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myeloproliferative neoplasms compared to the general population. (GWAS Catalog, Nature 2020, PMID:33057200)

Source: GWAS Catalog, Nature 2020, PMID:33057200

Questions about rs1327494

What is rs1327494?

rs1327494 is a single position in the genome, in or near the JAK2 gene. Published research associates it with myeloproliferative neoplasms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs1327494 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1327494 come from?

GWAS Catalog, Nature 2020, PMID:33057200. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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