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Low tan response

TYRP1 · rs1326797

Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

What the study found

Who was studied 46,768 European ancestry low tanning cases, 74,528 European ancestry moderate and high tanning controls; replicated in 15,547 European ancestry low tanning cases, 39,835 European moderate and high tanning ancestry controls.

The effect Each copy of the T allele shifted the measure 0.076 lower (95% confidence interval 0.025-0.127); p = 1 × 10⁻¹⁷.

Where it sits Chromosome 9, band 9p23 — in an intron of LURAP1L-AS1.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Low tan response — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Low tan response.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Low tan response compared to the general population.

Source

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

Visconti A, Duffy DL, Liu F, Zhu G, Wu W, Chen Y, Hysi PG, Zeng C, Sanna M, Iles MM, Kanetsky PA, Demenais F

and 10 more — show all

Hamer MA, Uitterlinden AG, Ikram MA, Nijsten T, Martin NG, Kayser M, Spector TD, Han J, Bataille V, Falchi M

Nature communications · 2018 · PMID 29739929 · open access

Questions about rs1326797

What is rs1326797?

rs1326797 is a single position in the genome, in or near the TYRP1 gene. Published research associates it with low tan response. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1326797 linked to?

On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.

Does having rs1326797 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1326797 come from?

GWAS Catalog, Nat Commun 2018, PMID:29739929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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