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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 6,758 European ancestry male cases, 1,670 European ancestry female cases, 7,489 European ancestry male controls, 6,174 European ancestry female controls.
The effect
Each copy of the C allele carried 0.62 times the odds of Barrett's esophagus or Esophageal adenocarcinoma (95% confidence interval 0.53-0.73); p = 7 × 10−9.
Where it sits Chromosome 8, band 8p23.1 — between genes, 23.7 kb from PRSS55.
What each result means
C/CTwo copies of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Barrett's esophagus or Esophageal adenocarcinoma. This is the starting point the study compared everyone against.
rs13259457 is a single position in the genome, in or near the PRSS55 gene. Published research associates it with barrett's esophagus or esophageal adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs13259457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13259457 come from?
GWAS Catalog, Gastroenterology 2020, PMID:32918910. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Barrett's esophagus or Esophageal adenocarcinoma (rs13259457). MyGeneLog™. https://www.mygenelog.com/variants/rs13259457