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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 460,198 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.00453 lower (95% confidence interval 0.003-0.0061); p = 7 × 10−9.
How common The C allele had a frequency of about 30% in the people studied.
Where it sits Chromosome 22, band 22q12.1 — in an intron of ZNRF3.
What each result means
C/CTwo copies of the version the research linked to Body shape phenotype PC4. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Body shape phenotype PC4. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Body shape phenotype PC4. This is the starting point the study compared everyone against.
Science advances · 2024 · PMID 38640244 · open access
Questions about rs132561
What is rs132561?
rs132561 is a single position in the genome, in or near the ZNRF3 gene. Published research associates it with body shape phenotype pc4. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs132561 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs132561 come from?
GWAS Catalog, Science advances 2024, PMID:38640244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body shape phenotype PC4 (rs132561). MyGeneLog™. https://www.mygenelog.com/variants/rs132561