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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,728 European ancestry cases, 7,758 European ancestry controls; replicated in 1,795 European ancestry cases, 5,586 European ancestry controls.
The effect
Each copy of the T allele carried 1.18 times the odds of Follicular lymphoma (95% confidence interval 1.11-1.24); p = 1 × 10−8.
How common The T allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 8, band 8q24.21 — in an intron of PVT1.
How common each version is
CT
KoreanKRGDB
C 79.6% · T 20.4%
KoreanKorea4K
C 80.6% · T 19.4%
KoreanKorea1K
C 80.5% · T 19.5%
Japanese ToMMo
C 80.9% · T 19.1%
World gnomAD
C 75.8% · T 24.1%
World 1000 Genomes
C 79.1% · T 20.9%
World TOPMed
C 76.9% · T 23.1%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
C/CNo copy of the version the research linked to Follicular lymphoma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Follicular lymphoma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Follicular lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs13254990
What is rs13254990?
rs13254990 is a single position in the genome, in or near the PVT1 gene. Published research associates it with follicular lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs13254990 linked to?
On MyGeneLog this position is linked to Follicular Lymphoma. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs13254990?
Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs13254990 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13254990 come from?
GWAS Catalog, Am J Hum Genet 2014, PMID:25279986. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 5032225223227Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity2Meta AI5Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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