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Childhood body mass index

ELP3 · rs13253111

Where this position leads

What the study found

Who was studied 34,744 European ancestry children; replicated in 11,313 European ancestry children.

The effect Each copy of the A allele shifted the measure 0.042 higher (95% confidence interval 0.028-0.056); p = 5 × 10⁻⁹.

How common The A allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 8, band 8p21.1 — between genes, 13.3 kb from ELP3.

What each result means

A/A Two copies of the version the research linked to Childhood body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Childhood body mass index. That is a smaller link than two copies.

G/G No copy of the version the research linked to Childhood body mass index. This is the starting point the study compared everyone against.

Source

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N

and 99 more — show all

Joro R, Cavadino A, Huikari V, Franks S, Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T, Curtin JA, Vioque J, Ahluwalia TS, Myhre R, Price TS, Vilor-Tejedor N, Yengo L, Grarup N, Ntalla I, Ang W, Atalay M, Bisgaard H, Blakemore AI, Bonnefond A, Carstensen L, Eriksson J, Flexeder C, Franke L, Geller F, Geserick M, Hartikainen AL, Haworth CM, Hirschhorn JN, Hofman A, Holm JC, Horikoshi M, Hottenga JJ, Huang J, Kadarmideen HN, Kähönen M, Kiess W, Lakka HM, Lakka TA, Lewin AM, Liang L, Lyytikäinen LP, Ma B, Magnus P, McCormack SE, McMahon G, Mentch FD, Middeldorp CM, Murray CS, Pahkala K, Pers TH, Pfäffle R, Postma DS, Power C, Simpson A, Sengpiel V, Tiesler CM, Torrent M, Uitterlinden AG, van Meurs JB, Vinding R, Waage J, Wardle J, Zeggini E, Zemel BS, Dedoussis GV, Pedersen O, Froguel P, Sunyer J, Plomin R, Jacobsson B, Hansen T, Gonzalez JR, Custovic A, Raitakari OT, Pennell CE, Widén E, Boomsma DI, Koppelman GH, Sebert S, Järvelin MR, Hyppönen E, McCarthy MI, Lindi V, Harri N, Körner A, Bønnelykke K, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Smith GD, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW

Bone Mineral Density in Childhood Study (BMDCS) · Early Genetics and Lifecourse Epidemiology (EAGLE) consortium · Early Growth Genetics (EGG) Consortium · Bone Mineral Density in Childhood Study BMDCS

Human molecular genetics · 2016 · PMID 26604143

Questions about rs13253111

What is rs13253111?

rs13253111 is a single position in the genome, in or near the ELP3 gene. Published research associates it with childhood body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13253111 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index. The research behind each link, and its sources, are set out on that condition page.

Does having rs13253111 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13253111 come from?

GWAS Catalog, Hum Mol Genet 2015, PMID:26604143. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Childhood body mass index (rs13253111). MyGeneLog™. https://www.mygenelog.com/variants/rs13253111

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