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Neuroticism

GRM8 · rs13224947

Where this position leads

Condition: Neuroticism

rs13224947 Condition: Neuroticism Neuroticism Condition rs13224947 rs13224947 GRM8

What the study found

Who was studied 329,821 European ancestry individuals; replicated in 122,867 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 7.53 higher; p = 5 × 10−14.

How common The A allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 7, band 7q31.33 — in an intron of GRM8.

What each result means

A/A Two copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/G No copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
Source

Questions about rs13224947

What is rs13224947?

rs13224947 is a single position in the genome, in or near the GRM8 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13224947 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs13224947 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13224947 come from?

GWAS Catalog, Nature genetics 2018, PMID:29255261. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs13224947). MyGeneLog™. https://www.mygenelog.com/variants/rs13224947

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