Sensitive

Colorectal cancer

near CASC20 · rs1321456

Where this position leads

Condition: Colorectal Cancer

rs1321456 Condition: Colorectal Cancer Colorectal Cancer Condition rs1321456 rs1321456 near CASC20

What the study found

Who was studied 15,714 European ancestry cases, 621,182 European ancestry controls, 7,062 East Asian ancestry cases, 195,745 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0591 lower; p = 2 × 10−11.

Where it sits Chromosome 20, band 20p12.3 — between genes, 38.7 kb from CASC20.

What each result means

A/A Two copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.
Source

Questions about rs1321456

What is rs1321456?

rs1321456 is a single position in the genome, in or near the near CASC20 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1321456 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs1321456 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1321456 come from?

GWAS Catalog, Genome medicine 2024, PMID:38872215. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colorectal cancer (rs1321456). MyGeneLog™. https://www.mygenelog.com/variants/rs1321456

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