Sensitive

Squamous cell lung carcinoma

ZSCAN12 · rs13213986

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 7,426 European ancestry cases, 55,627 European ancestry controls.

The effect Each copy of the A allele carried 1.25 times the odds of Squamous cell lung carcinoma (95% confidence interval 1.168376851-1.335481193); p = 7 × 10⁻¹¹.

How common The A allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — in the 3′ untranslated region of ZSCAN12.

What each result means

A/A Two copies of the version the research linked to Squamous cell lung carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Squamous cell lung carcinoma. That is a smaller link than two copies.

T/T No copy of the version the research linked to Squamous cell lung carcinoma. This is the starting point the study compared everyone against.

Source

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A

and 128 more — show all

Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI

SpiroMeta Consortium

Nature genetics · 2017 · PMID 28604730 · open access

Questions about rs13213986

What is rs13213986?

rs13213986 is a single position in the genome, in or near the ZSCAN12 gene. Published research associates it with squamous cell lung carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13213986 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13213986 come from?

GWAS Catalog, Nature genetics 2017, PMID:28604730. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Squamous cell lung carcinoma (rs13213986). MyGeneLog™. https://www.mygenelog.com/variants/rs13213986

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