Sensitive

Oropharynx cancer

MUC21 · rs13211972

What the study found

Who was studied 1,144 European ancestry cases, 4,493 European ancestry controls; replicated in 2,328 European ancestry cases, 3,232 European ancestry controls.

The effect Each copy of the A allele carried 1.55 times the odds of Oropharynx cancer (95% confidence interval 1.36-1.77); p = 1 × 10−10.

How common The A allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 1.3 kb from MUC21.

What each result means

A/A Two copies of the version the research linked to Oropharynx cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Oropharynx cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Oropharynx cancer. This is the starting point the study compared everyone against.
Source

Questions about rs13211972

What is rs13211972?

rs13211972 is a single position in the genome, in or near the MUC21 gene. Published research associates it with oropharynx cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13211972 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13211972 come from?

GWAS Catalog, Cancer research 2020, PMID:32276964. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Oropharynx cancer (rs13211972). MyGeneLog™. https://www.mygenelog.com/variants/rs13211972

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