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Aerodigestive squamous cell cancer (pleiotropy)

near ZSCAN9 · rs13204012

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 7,426 European ancestry lung squamous cell carcinoma cases, 5,452 European ancestry oral and oropharynx squamous cell carcinoma cases, 693 European ancestry laryngeal squamous cell carcinoma cases, 316 European ancestry esophageal squamous cell carcinoma cases, 61,961 European ancestry controls.

The effect Each copy of the A allele carried 1.22 times the odds of Aerodigestive squamous cell cancer (pleiotropy) (95% confidence interval 1.16-1.28); p = 3 × 10−12.

How common The A allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 6, band 6p22.1 — between genes, 0.3 kb from ZSCAN9.

What each result means

A/A Two copies of the version the research linked to Aerodigestive squamous cell cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Aerodigestive squamous cell cancer (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Aerodigestive squamous cell cancer (pleiotropy). This is the starting point the study compared everyone against.
Source
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
Lesseur C, Ferreiro-Iglesias A, McKay JD, Bossé Y, Johansson M, Gaborieau V, Landi MT, Christiani DC, Caporaso NC, Bojesen SE, Amos CI, Shete S
and 41 more — show all
Liu G, Rennert G, Albanes D, Aldrich MC, Tardon A, Chen C, Triantafillos L, Field JK, Teare MD, Kiemeney LA, Diergaarde B, Ferris RL, Zienolddiny S, Lam S, Olshan AF, Weissler MC, Lacko M, Risch A, Bickeböller H, Ness AR, Thomas S, Le Marchand L, Schabath MB, Wünsch-Filho V, Tajara EH, Andrew AS, Clifford GM, Lazarus P, Grankvist K, Johansson M, Arnold S, Melander O, Brunnström H, Boccia S, Cadoni G, Timens W, Obeidat M, Xiao X, Houlston RS, Hung RJ, Brennan P
PLoS genetics · 2021 · PMID 33667223 · open access

Questions about rs13204012

What is rs13204012?

rs13204012 is a single position in the genome, in or near the near ZSCAN9 gene. Published research associates it with aerodigestive squamous cell cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs13204012 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13204012 come from?

GWAS Catalog, PLoS genetics 2021, PMID:33667223. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Aerodigestive squamous cell cancer (pleiotropy) (rs13204012). MyGeneLog™. https://www.mygenelog.com/variants/rs13204012

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