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Brown vs. black hair color

EXOC2 · rs13192740

Where this position leads

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁷, with 11 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 269,394 British ancestry brown hair individuals, 14,526 British ancestry black hair individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 1 × 10⁻⁹.

How common The C allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 6, band 6p25.3 — in an intron of EXOC2.

How common each version is

CT

Korean KRGDB

C 44.7% · T 55.3%

Korean Korea4K

C 43.1% · T 56.9%

Korean Korea1K

C 44.8% · T 55.2%

Japanese ToMMo

C 35.5% · T 64.5%

Vietnamese

C 58.4% · T 41.6%

World gnomAD

C 54.6% · T 45.4%

World 1000 Genomes

C 54.7% · T 45.3%

World TOPMed

C 56.8% · T 43.2%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to Brown vs. black hair color. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Brown vs. black hair color. That is a smaller link than two copies.

T/T No copy of the version the research linked to Brown vs. black hair color. This is the starting point the study compared everyone against.

Source

Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability

Morgan MD, Pairo-Castineira E, Rawlik K, Canela-Xandri O, Rees J, Sims D, Tenesa A, Jackson IJ

Nature communications · 2018 · PMID 30531825 · open access

Questions about rs13192740

What is rs13192740?

rs13192740 is a single position in the genome, in or near the EXOC2 gene. Published research associates it with brown vs. black hair color. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13192740 linked to?

On MyGeneLog this position is linked to Hair Color. The research behind each link, and its sources, are set out on that condition page.

Does having rs13192740 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13192740 come from?

GWAS Catalog, Nat Commun 2018, PMID:30531825. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Brown vs. black hair color (rs13192740). MyGeneLog™. https://www.mygenelog.com/variants/rs13192740

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