Sensitive

Psoriatic arthritis

HLA-C · rs13191343

Where this position leads

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10⁻⁷², with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 572 European ancestry cases, 888 European ancestry controls; replicated in Up to 1,761 European ancestry cases, 3,727 European ancestry controls.

The effect Each copy of the T allele carried 2.37 times the odds of Psoriatic arthritis (95% confidence interval 2.16-2.61); p = 2 × 10⁻⁷².

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 1.2 kb from HLA-C.

How common each version is

CT

Korean KRGDB

C 92.0% · T 8.1%

Korean Korea4K

C 92.1% · T 7.9%

Japanese ToMMo

C 89.1% · T 10.9%

World gnomAD

C 86.9% · T 13.1%

World 1000 Genomes

C 86.0% · T 14.0%

World TOPMed

C 87.1% · T 12.9%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Psoriatic arthritis. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Psoriatic arthritis. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Psoriatic arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis

Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW

and 18 more — show all

Behrens F, Lascorz J, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A

Nature genetics · 2010 · PMID 20953186 · open access

Questions about rs13191343

What is rs13191343?

rs13191343 is a single position in the genome, in or near the HLA-C gene. Published research associates it with psoriatic arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13191343 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs13191343 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13191343 come from?

GWAS Catalog, Nat Genet 2010, PMID:20953186. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriatic arthritis (rs13191343). MyGeneLog™. https://www.mygenelog.com/variants/rs13191343

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