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Who was studied 523,783 European ancestry individuals; replicated in 59,206 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.018 higher (95% confidence interval 0.012-0.024); p = 4 × 10−8.
How common The G allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 5, band 5q14.3 — in an intron of MEF2C-AS2.
What each result means
A/ANo copy of the version the research linked to Neuroticism. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Neuroticism. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Neuroticism. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs13170975 is a single position in the genome, in or near the MEF2C-AS2 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs13170975 linked to?
On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.
Does having rs13170975 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13170975 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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