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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 121,934 European ancestry cases, 591,699 European ancestry controls.
The effect
Each copy of the G allele carried 1.05 times the odds of Age-related hearing impairment; p = 4 × 10−11.
Where it sits Chromosome 4, band 4p15.32 — a missense change in CLRN2.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Age-related hearing impairment — no copies of the reported risk allele.
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Age-related hearing impairment.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Age-related hearing impairment compared to the general population.
Communications biology · 2021 · PMID 34108613 · open access
Questions about rs13147559
What is rs13147559?
rs13147559 is a single position in the genome, in or near the CLRN2 gene. Published research associates it with age-related hearing impairment. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs13147559 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13147559 come from?
GWAS Catalog, Communications biology 2021, PMID:34108613. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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