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Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the T allele shifted the measure 0.01 mmol/L higher (95% confidence interval 0.01-0.01); p = 5 × 10−11.
Where it sits Chromosome 4, band 4q31.21 — in an intron of SMAD1-AS2.
What each result means
C/CNo copy of the version the research linked to Concentration of medium HDL particles. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Concentration of medium HDL particles. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Concentration of medium HDL particles. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs13134992
What is rs13134992?
rs13134992 is a single position in the genome, in or near the near SMAD1 gene. Published research associates it with concentration of medium hdl particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs13134992 linked to?
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
Does having rs13134992 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13134992 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Concentration of medium HDL particles (rs13134992). MyGeneLog™. https://www.mygenelog.com/variants/rs13134992