Standard

Post bronchodilator FEV1/FVC ratio

near KRT18P51 · rs13118928

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 10,094 European ancestry current and former smoker individuals, 3,260 African American current and former smoker individuals, 178 current and former smoker individuals.

The effect Each copy of the A allele shifted the measure 0.016 lower; p = 3 × 10⁻¹⁶.

How common The A allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 4, band 4q31.21 — between genes, 7 kb from KRT18P51.

What ClinVar records

Classification association for Chronic obstructive pulmonary disease, Chronic obstructive pulmonary disease, biomass related; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2020-02-12. ClinVar record 870130 NC_000004.12:g.144565237A>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Post bronchodilator FEV1/FVC ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Post bronchodilator FEV1/FVC ratio. That is a smaller link than two copies.

G/G No copy of the version the research linked to Post bronchodilator FEV1/FVC ratio. This is the starting point the study compared everyone against.

Source

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ

and 12 more — show all

Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK

ECLIPSE Investigators · COPDGene Investigators

BMC genetics · 2015 · PMID 26634245 · open access

Questions about rs13118928

What is rs13118928?

rs13118928 is a single position in the genome, in or near the near KRT18P51 gene. Published research associates it with post bronchodilator fev1/fvc ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13118928 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs13118928 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13118928 come from?

GWAS Catalog, BMC genetics 2015, PMID:26634245. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Post bronchodilator FEV1/FVC ratio (rs13118928). MyGeneLog™. https://www.mygenelog.com/variants/rs13118928

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