Sensitive

Cervical cancer

EXOC1 · rs13117307

Where this position leads

What the study found

Who was studied Up to 1,364 Han Chinese ancestry cases, up to 3,028 Han Chinese ancestry controls; replicated in 4,167 Han Chinese ancestry cases, 7,196 Han Chinese ancestry controls.

The effect Each copy of the T allele carried 1.28 times the odds of Cervical cancer (95% confidence interval 1.19-1.38); p = 3 × 10⁻¹⁰.

How common The T allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 4, band 4q12 — in an intron of EXOC1.

What each result means

C/C No copy of the version the research linked to Cervical cancer. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Cervical cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Cervical cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12

Shi Y, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y

and 72 more — show all

Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X, Ma D

Nature genetics · 2013 · PMID 23817570

Questions about rs13117307

What is rs13117307?

rs13117307 is a single position in the genome, in or near the EXOC1 gene. Published research associates it with cervical cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13117307 linked to?

On MyGeneLog this position is linked to Cervical Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs13117307 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13117307 come from?

GWAS Catalog, Nat Genet 2013, PMID:23817570. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cervical cancer (rs13117307). MyGeneLog™. https://www.mygenelog.com/variants/rs13117307

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