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Serum 25-Hydroxyvitamin D levels

GC · rs13107347

Where this position leads

Condition: Vitamin D Deficiency and the GC Gene

rs13107347 Condition: Vitamin D Deficiency and the GC Gene Vitamin D Deficiency and the GC Gene Condition rs13107347 rs13107347 GC

What the study found

Who was studied 8,541 African American individuals, 3,485 Hispanic American individuals, 16,124 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 6.14 (z-score) higher (95% confidence interval -); p = 8 × 10−10.

How common The C allele had a frequency of about 33% in the people studied.

Where it sits Chromosome 4, band 4q13.3 — in an intron of NPFFR2.

What each result means

C/C Two copies of the version the research linked to Serum 25-Hydroxyvitamin D levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Serum 25-Hydroxyvitamin D levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to Serum 25-Hydroxyvitamin D levels. This is the starting point the study compared everyone against.
Source
Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations
Hong J, Hatchell KE, Bradfield JP, Bjonnes A, Chesi A, Lai CQ, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA
and 48 more — show all
Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanghera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK
The Journal of clinical endocrinology and metabolism · 2018 · PMID 29325163

Questions about rs13107347

What is rs13107347?

rs13107347 is a single position in the genome, in or near the GC gene. Published research associates it with serum 25-hydroxyvitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13107347 linked to?

On MyGeneLog this position is linked to Vitamin D Deficiency and the GC Gene. The research behind each link, and its sources, are set out on that condition page.

Does having rs13107347 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13107347 come from?

GWAS Catalog, J Clin Endocrinol Metab 2018, PMID:29325163. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum 25-Hydroxyvitamin D levels (rs13107347). MyGeneLog™. https://www.mygenelog.com/variants/rs13107347

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