Gene Knowledge Graph UTC
Sensitive

Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies)

DGKQ · rs13101828

Where this position leads

Condition: Systemic Lupus Erythematosus

rs13101828 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs13101828 rs13101828 DGKQ

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) — no copies of the reported risk allele. (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies). (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) compared to the general population. (GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655)
Source
Genome-wide meta-analysis reveals shared new <i>loci</i> in systemic seropositive rheumatic diseases
Acosta-Herrera M, Kerick M, González-Serna D, Wijmenga C, Franke A, Gregersen PK, Padyukov L, Worthington J, Vyse TJ, Alarcón-Riquelme ME, Mayes MD, Martin J
Myositis Genetics Consortium · Scleroderma Genetics Consortium
Annals of the rheumatic diseases · 2019 · PMID 30573655

Questions about rs13101828

What is rs13101828?

rs13101828 is a single position in the genome, in or near the DGKQ gene. Published research associates it with systemic seropositive rheumatic diseases (systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs13101828 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs13101828 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs13101828 come from?

GWAS Catalog, Ann Rheum Dis 2018, PMID:30573655. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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