EBV read positivity (EBV-read count 1-18)
LPP · rs13098877
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 56,180 European ancestry cases, 304,103 European ancestry controls; replicated in 184,948 European ancestry individuals.
The effect Each copy of the C allele shifted the measure 0.0781 lower (95% confidence interval 0.065-0.091); p = 3 × 10−31.
How common The C allele had a frequency of about 56% in the people studied.
Where it sits Chromosome 3, band 3q28 — in an intron of LPP.
What each result means
In the news
2026-02-19 · Schmidt A, et al., Nature 2026, PMID:41714741
Host control of persistent Epstein-Barr virus infection
Epstein-Barr virus infects roughly 90-95% of people and stays for life in B cells. This study read EBV out of ordinary blood-based genome sequencing: EBV reads turned up in 16.2% of 486,315 UK Biobank participants and 21.8% of 336,123 All of Us participants, tracking higher viral load in blood cells, and were more common with HIV infection, immunosuppressive drugs and current smoking. Genome-wide, the strongest signals were in the MHC — 54 independent HLA alleles across classes I and II — plus 27 regions outside it, with an interaction between HLA class I alleles and the ERAP2 locus. People with EBV-associated diseases carried a higher polygenic burden of the EBV-positive signal: at MHC class I in multiple sclerosis (driven by HLA-A*02:01) and at MHC class II in rheumatoid arthritis, with polygenic overlap also seen for inflammatory bowel disease, hypothyroidism and type 1 diabetes. Four of the study's non-MHC positions are already on this site — rs13098877 (LPP), rs884186 (KSR1), rs9828869 (near ILDR1) and rs34557412 (TNFRSF13B) — the last also linked here to lymphocyte count. PMID:41714741.
From our blog
Questions about rs13098877
What is rs13098877?
rs13098877 is a single position in the genome, in or near the LPP gene. Published research associates it with ebv read positivity (ebv-read count 1-18). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs13098877 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13098877 come from?
GWAS Catalog, Nature 2026, PMID:41714741. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
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EBV read positivity (EBV-read count 1-18) (rs13098877). MyGeneLog™. https://www.mygenelog.com/variants/rs13098877