LPP · rs13093110
Where this position leads
Condition: Autoimmune Thyroid Disease
What the study found
Who was studied 2,282 European ancestry Graves disease cases, 451 European ancestry Hashimoto's thyroiditis cases, 9364 European ancestry controls.
The effect Each copy of the T allele carried 1.19 times the odds of Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) (95% confidence interval 1.12–1.26] ); p = 4 × 10−8.
How common The T allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 3, band 3q28 — in an intron of LPP.
rs13093110 is a single position in the genome, in or near the LPP gene. Published research associates it with autoimmune thyroid diseases (graves disease or hashimoto's thyroiditis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Autoimmune Thyroid Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2012, PMID:22922229. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.